Three dimensional chromatin structure of umbilical cord endothelial cells from modern Tibetan population in Tibet (2010-2020)- A Big Earth Data Platform for Three Poles

1) Data content: this data is the chromatin open group data of umbilical cord endothelial cells of Plateau Tibetan and plain Han people generated during the implementation of the project, including 5 cases of Plateau Tibetan umbilical cord endothelial cell chromatin open group data and 5 cases of plain Han umbilical cord endothelial cell chromatin open group data. The amount of chromatin open group data of each cell is > 15g sequencing depth, which can be used to study the high-risk factors The chromatin opening pattern and gene expression regulation pattern of the original Tibetan population and the plain Han population in high altitude hypoxia environment.

2) Data sources and processing methods: Based on our own data, we used the 150 BP pair end sequencing method of Illumina x-ten.

3) Data quality: > 15g data volume, q30 > 90%.

4) Data application achievements and prospects: the data are used to verify the open mode of cell chromatin and gene expression change mode of high altitude hypoxia adaptation genes under hypoxia environment.

File naming and required software

A is adaptive cell of Tibetan nationality; W is not adaptive cell of Han nationality.

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Cite as:

Qi, X. (2021). Three dimensional chromatin structure of umbilical cord endothelial cells from modern Tibetan population in Tibet (2010-2020). A Big Earth Data Platform for Three Poles, DOI: 10.11888/Ecolo.tpdc.271201. CSTR: 18406.11.Ecolo.tpdc.271201. (Download the reference： RIS | Bibtex )

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References literature

1.Xin, J., Zhang, H., He, Y., Duren, Z., Bai, C., Chen, L., Luo, X., Yan, D., Zhang, C., Zhu, X., Yuan, Q., Cui, C., Qi, X., Ouzhuluobu, Wong, W.H., Wang, Y. & Su, B. Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation. Nature Communications, 11, 4928 (2020). (View Details | Download )

Support Program

Pan-Third Pole Environment Study for a Green Silk Road-A CAS Strategic Priority A Program (No:XDA20000000)

Copyright & License

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License： This work is licensed under an Attribution 4.0 International (CC BY 4.0)